We'll have the Chicken article another day ... and I'm sorry I don't trust you folks to actually follow links ...
I specualte that since few can make the connection between Cheney's silencing a “pal” re: Funeralgate and a 'shooting accident' that even fewer will make one between a phony war and the impending Bird Flu pandemic due real soon now. It isn't just Sparky who can add 2 + 2. He counts on you as well —
Funeralgate
"Funeralgate" is the name given to a scandal involving George W. Bush and family campaign contributor Robert Waltrip, owner of Service Corporation International, the largest funeral home company in the world.
In 1999, Bush was subpoenaed but refused to testify in a lawsuit filed against the state of Texas and SCI by Eliza May, former director of the Texas Funeral Service Commission, who claimed that she was fired when she refused to quit investigating SCI despite pressure from Bush and his then Chief of Staff Joe Allbaugh.
The lawsuit was quietly settled in November, 2001, weeks before the revelation in the media that two Florida cemeteries owned by SCI were recycling graves, removing remains from their places of rest and placing other people in the graves.
9,000 people have staked a claim to a $100,000,000 settlement in a lawsuit stemming from the desecration of graves at these cemeteries.
In one instance at Menorah Gardens, a Jewish cemetery, SCI desecrated graves and left corpses in the woods where they were devoured by wild hogs.
The general manager of Menorah Gardens, Peter Hartman, died by apparent suicide on December 27, 2001.[1]In February 2006, Whittington was shot in the face by Vice President Dick Cheney in an apparent hunting accident.
SCI was later awarded a no-bid contract by FEMA to count and collect corpses in Louisiana after Hurricane Katrina.
Links- Gruesome Photos, Video Show Bodies Discarded in Woods Behind Cemetery from Fox News
- Bush faces questions over funeral home dispute from CNN
- Bush Need Not Testify, Judge Rules from the Washington Post
- Governor approves the settlement of lawsuit involving President Bush from the Corpus Cristi Caller Times
- 9,000 stake settlement claim in Florida Jewish cemetery desecration case from HAARETZ Daily
- La. outsource Katrina body count to firm implicated in body-dumping scandals
- Kenyon International Activates Emergency Team for Hurricane Katrina Response
- Florida adds new lawsuit to cemetery firm's woes
- Service Corporation International Announces Settlement of Florida Litigation
- Bush Need Not Testify, Judge Rules
- Funeral Scandal Is a Real Scene Stealer
- "Funeralgate" Now Involves Georgia, Too
- Georgia crematory operator faces Friday court date
- Governor approves the settlement of lawsuit involving President Bush
- Central figure in cemetery probe found dead
- http://www.democrats.com/node/5960 Joe 'Funeralgate' Allbaugh Destroyed FEMA
- The Missing and the Dead Part VI (a continuing archive)
- FEMA, La. outsource Katrina body count to firm implicated in body-dumping
Bush Junta 2 's Phony Rush to War Must be Blamed For Bird Flu Flourishing
Stay with me on this — We know due to the Downing Street memo that Bush's Chickenhawk Top Traitors lied to get us to invade Iraq:
Northern Iraq's border with Turkey is where the pandemic could have been slowed or stopped. Heaven knows that not allowing Gay daddies to wed is more important to the teeming millions who let the poor in New Orleans drown. I can only hope that W will rot in prison one day.... The minutes were meant to be kept confidential and are headed "This record is extremely sensitive. No further copies should be made. It should be shown only to those with a genuine need to know its contents." It deals with the lead-up to the 2003 Iraq War, and comes at a point at which it becomes clear to those attending, that US President George W. Bush intended to remove Saddam Hussein from power by force.
The minutes run through the military options and then consider the political strategy in which an appeal for support from the international community and from domestic opinion would be most likely to be positively received. It suggests that an ultimatum for Saddam to allow back United Nations weapons inspectors be issued, and that this would help to make the use of force legal. Tony Blair is quoted as saying that the British public would support regime change in the right political context. ...
Bird flu could kill between 1.4 and 140 million people - Australian researchers
February 17, 2006
- Australian bird flu vaccine trial results "promising"
- Bird flu could kill between 1.4 and 140 million people - Australian researchers
- Europe restricts poultry as bird flu spreads to eight European nations
- Hospital morale vital during any outbreak: expert warns
- Bird flu spreading through Indonesia and China
Disease | Year | Death toll |
---|---|---|
Spanish Flu | 1918/1919 | 50 million |
Asian Flu | 1957 | 1 million |
Hong Kong Flu | 1968 | 1 million |
H5N1 | Ongoing | 91 |
Two Australian researchers at the Australian National University estimate that a global pandemic of the deadly H5N1 strain of bird flu could kill between 1.4 and 140 million humans and cause a global recession. They will formally present their research to the Lowy Institute in Sydney today.
Professor Warwick McKibbin, a well respected economic modeller and member of the board of the Reserve Bank of Australia and health expert, Dr Alexandra Sidorenko modelled the effect of a bird flu pandemic on human health and the global economy. Their study looks at four possible scenarios - mild, moderate, severe and extreme.
Under the mild scenario, they predict that 1.4 million people worldwide and 2,100 Australians would die. The extreme scenario predicts 140 million worldwide deaths with 214,000 Australians among them. 30 percent of the Australian population would be expected to become infected should a pandemic occur.
In the extreme case, the global ecomomy would suffer losses of US$4.4 trillion or 12.6 percent.
Prof. McKibbin says that his economic estimates do not only include the cost of death but also for lost productivity. In an interview with ABC, Professor McKibbin said "Firstly, there's a reduction in the labour force. Now, interestingly it's not just that people die which is causing economic loss, but actually there is a substantial amount of illness in any influenza pandemic. "
"And so we try and capture both the death and the impact of that on the economy as well as illness during the pandemic, and including the fact that different economies have different labour market structures and that it's not just workers that get sick but also children, and we try to model the fact that carers will be taking time off work. " said Prof. McKibbin.
Pandemics have broken out every 10 to 40 years since the 19th century. The last pandemic was in 1968 caused by the Hong Kong flu.
"It is 37 years since the last pandemic and many argue that another pandemic is overdue," warns the report. The report advises investment in Asia, where health systems are less developed.
Sources
- Mark Colvin "Study looks at potential effects of bird flu pandemic". Australian Broadcasting Corporation, February 16, 2006
- Tara Raven "Bird flu could kill 214,000 Australians". The Daily Telegraph, February 16, 2006
- "Bird flu pandemic would 'kill millions, shut down economy'". Australian Broadcasting Coproration, February 16, 2006
- H5N1 confirmed in France - February 18, 2006 WikiNews
H5N1
H5N1 is an avian influenza virus subtype. The H5N1 flu is what is commonly meant when talking of "bird flu" or "avian influenza". It is a viral disease that causes illness in many species including humans and is a pandemic threat.
H5N1 is widespread in the bird population. It is very easy for birds to catch avian flu one from another. Humans will only catch it if they have a lot of physical contact with infected birds, or, rarely, an infected relative; for example, no professional health worker has caught the disease. While H5N1 is mutating into variations which infect species not previously known to carry the virus, not all of these variations can infect humans. It may eventually mutate into a form that is easily transmitted from human to human.
A highly pathogenic variation of H5N1 is currently spreading across the world from areas where it is endemic. Migrating waterfowl (wild ducks, geese, and swans) carry H5N1, often without themselves becoming sick.[1][2] Avian flu is also spread through domestic poultry, both through movements of infected birds and poultry products, and the use of infected poultry manure as fertiliser or feed. Humans with H5N1 have typically caught it from chickens, which were in turn infected by other poultry or waterfowl.
H5N1 is currently endemic in birds in southeast Asia and is threatening to become endemic in birds in west Asia and Africa. Current evidence from the latest outbreaks in Turkey show a hemagglutinin mutation making H5N1 easier to pass from chickens to humans, but not yet easier to pass from human to human[3]. Species killed by H5N1 infection in this December 2005 and January 2006 outbreak in Turkey include humans, chickens, turkeys, ducks, geese, and pigeons[4]. In January 2006 an H5N1 outbreak began in Nigeria.
Not all cases of H5N1 infection are reported and consequently the exact mortality rate is unknown. Earlier historical flu pandemics, which were also believed to be of avian origin, had reportedly an average mortality rate of 2.5-5%.
Tens of millions of birds have died of H5N1 influenza and hundreds of millions of birds have been slaughtered and disposed of to protect humans from H5N1[2]. Countries that have reported one or more major H5N1 outbreaks in birds are (in order of first outbreak occurance): Korea, Vietnam, Japan, Thailand, Cambodia, Laos, Indonesia, China, Malaysia, Russia, Kazakhstan, Mongolia, Turkey, Romania, Croatia, Ukraine, Cyprus, Iraq, Nigeria, Egypt, India. [5] H5N1 has been found in birds in the wild in numerous other countries; such as Austria, Azerbaijan, Bulgaria, France, Germany, Greece, Iran, Italy, Kuwait, Slovenia. There have been, so far, no outbreaks in any non-bird species.
The current projected worst case scenario for a H5N1 pandemic is somewhere around 150 million human deaths directly due to H5N1 infection (or two to three percent of the world's human population). No one knows what the chances are for this worst case scenario.
Avian Flu
<>Colorized transmission electron micrograph of H5N1 (golden) grown in Madin-Darby canine kidney cells (green). (Source: C. Goldsmith, J. Katz and S. Zaki. Centers for Disease Control & Prevention Public Health Image Library. Image #1841.).
H5N1 is a subtype of the species called avian influenza virus (bird flu). Avian flu is a disease and avian flu virus is a species. The avian flu virus subtypes are labeled according to an H number and an N number.
The avian influenza subtypes that have been confirmed in humans, ordered by the number of known human deaths, are: H1N1 caused "Spanish Flu", H2N2 caused "Asian Flu", H3N2 caused "Hong Kong Flu", H5N1 is the current pandemic threat, H7N7 has unusual zoonotic potential, H1N2 is currently endemic in humans and pigs, H9N2, H7N2, H7N3, H10N7.
The annual flu (also called "seasonal flu" or "human flu") kills an estimated 36,000 people in the United States each year. The dominant strain of annual flu virus in January 2006 was H3N2 which is now resistant to the standard antiviral drugs amantadine and rimantadine.
Avian influenza virus H3N2 is endemic in pigs ("swine flu") in China and has been detected in pigs in Vietnam, increasing fears of the emergence of new variant strains. Health experts say pigs can carry human influenza viruses, which can combine (i.e. exchange homologous genome sub-units by genetic reassortment.) with H5N1, swapping genes and mutating into a form which can pass easily among humans. A combination of these two subtypes of the species known as the avian flu virus in a country like China is a worst case scenerio.
Resources
- Official - international
- UN United Nations
- WHO World Health Organization
- The United Nation's World Health Organization's Avian Flu Facts Sheet for 2006
- Epidemic and Pandemic Alert and Response Guide to WHO's H5N1 pages
- Avian Influenza Resources (updated) - tracks human cases and deaths
- National Influenza Pandemic Plans
- WHO Collaborating Centres and Reference Laboratories Centers, names, locations, and phone numbers
- FAO Avian Influenza portal Information resources, animations, videos, photos
- FAO Food and Agriculture Organisation - Bi-weekly Avian Influenza Maps - tracks animal cases and deaths
- FAO Bird Flu disease card
- FAO Socio-Economic impact of AI Projects, Information resources
- WHO World Health Organization
- OIE World Organisation for Animal Health - tracks animal cases and deaths
- Official - United States
- PandemicFlu.Gov U.S. Government's avian flu information site
- USAID U.S. Agency for International Development - Avian Influenza Response
- CDC Centers for Disease Control - responsible agency for avian influenza in humans in US - Facts About Avian Influenza (Bird Flu) and Avian Influenza A (H5N1) Virus
- NWHC National Wildlife Health Center - responsible agency for avian influenza in animals in US
- HHS U.S. Department of Health & Human Services - Pandemic Influenza Plan
- Technical
- Influenza Report 2006 Online book. Research level quality information. Highly recommended.
- Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution Nature magazine presents a summary of what has been discovered in the Influenza Genome Sequencing Project.
- Links and descriptions to abstracts and full texts This bibliography of avian influenza publications was complied through the cooperative effort of the USGS National Wildlife Health Center and the Wildlife Disease Information Node.
- Search for research publications about H5N1: Entez PubMed
- Latest publications on H5N1
- Full HTML text of Avian Influenza A (H5N1) Infection in Humans by The Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5 in the 29 September 2005 New England Journal of Medicine
- Evolutionary "Tree of Life" for H5N1:
- Here is the phylogenetic tree of the influenza virus hemagglutinin gene segment. Amino acid changes in three lineages (bird, pig, human) of the influenza virus hemagglutinin protein segment HA1.
- Here is the tree showing the evolution by reassortment of H5N1 from 1999 to 2004 that created the Z genotype in 2002.
- Here is the tree showing evolution by antigenic drift since 2002 that created dozens of highly pathogenic varieties of the Z genotype of avian flu virus H5N1, some of which are increasingly adopted to mammals.
- Evolutionary characterization of the six internal genes of H5N1 human influenza A virus
- Genome database Page links to the complete sequence of the Influenza A virus (A/Goose/Guangdong/1/96(H5N1)) genome.
- News and General information
Please see Global spread of H5N1.
Confirmed human cases of avian influenza of type A (H5N1) As of February 13, 2006 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Country | Report dates | edit this table Total | |||||||||||||
2003 | 2004 | 2005 | 2006 | ||||||||||||
cases | deaths | cases | deaths | cases | deaths | cases | deaths | cases | deaths | ||||||
Cambodia | 4 | 4 | 100 % | 4 | 4 | 100 % | |||||||||
China | 8 | 5 | 62.5% | 4 | 3 | 75.0 % | 12 | 8 | 66.7% | ||||||
Indonesia | 17 | 11 | 64.7% | 8 | 7 | 87.5% | 25 | 18 | 72.0% | ||||||
Iraq | 1 | 1 | 100 % | 1 | 1 | 100 % | |||||||||
Thailand | 17 | 12 | 70.6% | 5 | 2 | 40.0% | 22 | 14 | 63.6% | ||||||
Turkey | 12 | 4 | 33.3% | 12 | 4 | 33.3% | |||||||||
Vietnam | 3 | 3 | 100 % | 29 | 20 | 69.0% | 61 | 19 | 31.1% | 93 | 42 | 45.2% | |||
Total | 3 | 3 | 100 % | 46 | 32 | 69.6% | 95 | 41 | 43.2% | 25 | 15 | 60.0% | 169 | 91 | 53.8% |
Source World Health Organization (WHO) : Communicable Disease Surveillance & Response (CSR). |
Influenzavirus A
|
2. New virus 3. Self limiting 4. Person to person 5. Epidemic exists 6. Pandemic exists |
Disease | Year | Death toll |
---|---|---|
Spanish Flu | 1918/1919 | 50 million |
Asian Flu | 1957 | 1 million |
Hong Kong Flu | 1968 | 1 million |
H5N1 | Ongoing | 91 |
Variants and subtypes
Variants of this species are sometimes named according to the species the strain is endemic in or adapted to. The main variants named using this convention are:
Variants are also sometimes named according to their deadliness in chickens:
- Low Pathogenic Avian Influenza (LPAI)
- Highly Pathogenic Avian Influenza (HPAI), also called: deadly flu or death flu
The avian flu virus subtypes are labeled according to an H number (for hemagglutinin) and an N number (for neuraminidase). Each subtype virus has mutated into a variety of strains with differing pathogenic profiles; some pathogenic to one species but not others, some pathogenic to multiple species. Most known strains are extinct strains. For example, the annual flu subtype H3N2 no longer contains the strain that caused the Hong Kong Flu.
Avian influenza viruses are negative sense, single-stranded, segmented RNA viruses. "There are 16 different HA antigens (H1 to H16) and nine different NA antigens (N1 to N9) for influenza A. Until recently, 15 HA types had been recognized, but a new type (H16) was isolated from black-headed gulls caught in Sweden and the Netherlands in 1999 and reported in the literature in 2005." [2]
Annual flu
- Main article: Flu season
The annual flu (also called "seasonal flu" or "human flu") kills an estimated 36,000 people in the United States each year. The annually updated trivalent flu vaccine consists of hemagglutinin (HA) surface glycoprotein components from influenza H3N2, H1N1, and B influenza viruses. [3] The dominant strain in January 2006 is H3N2. Measured resistance to the standard antiviral drugs amantadine and rimantadine in H3N2 has increased from 1% in 1994 to 12% in 2003 to 91% in 2005. [4] [5] "[C]ontemporary human H3N2 influenza viruses are now endemic in pigs in southern China and can reassort with avian H5N1 viruses in this intermediate host." [6]
Genetics
Influenza A viruses contain their genome in eight separate linear segments of negative-sense RNA, which code for ten proteins (eleven for type A if including the novel PB1-F1 protein). Each segment contains a single gene, but some can be read twice at different starting points to create two distinct proteins. The segmented nature of the genome also allows for the exchange of entire genes between different viral strains when they cohabitate the same cell. The 8 genes are:
- HA gene encoding hemagglutinin (about 500 molecules of hemagglutinin are needed to make one virion) "The extent of infection into host organism is determined by HA. Influenza viruses bud from the apical surface of polarized epithelial cells (e.g. bronchial epithelial cells) into lumen of lungs and are therefore usually pneumotropic. The reason is that HA is cleaved by tryptase clara which is restricted to lungs. However HAs of H5 and H7 pantropic avian viruses subtypes can be cleaved by furin and subtilisin-type enzymes, allowing the virus to grow in other organs than lungs." [7]
- NA gene encoding neuraminidase (about 100 molecules of neuraminidase are needed to make one virion)
- NP gene encoding nucleoprotein. Influenza A, B, and C are distinguished by their nucleoproteins
- M gene encoding two matrix proteins (the M1 and the M2) by using different reading frames from the same RNA segment (about 3000 matrix protein molecules are needed to make one virion)
- NS gene encoding two distinct non-structural proteins by using different reading frames from the same RNA segment
- PA gene encoding an RNA polymerase
- PB1 gene encoding an RNA polymerase and PB1-F2 protein (induces apoptosis) by using different reading frames from the same RNA segment
- PB2 gene encoding an RNA polymerase
The genome segments have common terminal sequences, and the ends of the RNA strands are partially complementary, allowing them to bond to each other by hydrogen bonds. After transcription from negative-sense to positive-sense RNA the +RNA strands get the cellular 5' cap added, allowing its processing as messenger RNA by ribosomes. The +RNA strands also serve for synthesis of -RNA strands for new virions.
The RNA synthesis and its assembly with the nucleoprotein takes place in the cell nucleus, the synthesis of proteins takes place in the cytoplasm. The assembled virion cores leave the nucleus and migrate towards the cell membrane, with patches of viral transmembrane proteins (hemagglutinin, neuraminidase and M2 proteins) and an underlying layer of the M1 protein, and bud through these patches, releasing finished enveloped viruses into the extracellular fluid.
In nonhumans
- See H5N1 for the current epizootic (an epidemic in nonhumans) and panzootic (a disease affecting animals of many species especially over a wide area) of H5N1 influenza
Wild fowl act as natural asymptomatic carriers of avian flu virus. Prior to the current H5N1 epizootic, strains of avian influenza virus had been demonstrated to be transmitted from wild fowl to only birds, pigs, horses, seals, whales and humans; and only between humans and pigs and between humans and domestic fowl; and not other pathways such as domestic fowl to horse. [8] H5N1 has been shown to be also transmitted to tigers, leopards, and domestic cats who were fed uncooked domestic fowl (chickens) with the virus. H3N8 viruses from horses have crossed over and caused outbreaks in dogs. Laboratory mice have been successfully infected with a variety of avian flu genotypes. [9]
Avian influenza virus spreads in the air and in manure and survives longer in cold weather. It can also be transmitted by contaminated feed, water, equipment and clothing; however, there is no evidence that the virus can survive in well cooked meat. The incubation period is 3 to 5 days. Symptoms in animals vary, but virulent strains can cause death within a few days.
"Highly pathogenic avian influenza virus is on every top ten list available for potential agricultural bioweapon agents". [10]
Avian influenza viruses that the OIE and others test for in order to control poultry disease include: H5N1, H7N2, H1N7, H7N3, H13N6, H5N9, H11N6, H3N8, H9N2, H5N2, H4N8, H10N7, H2N2, H8N4, H14N5, H6N5, H12N5 and others. [11]
Year | Area | Affected | Strain |
---|---|---|---|
1959 | Scotland | chicken | H5N1 |
1963 | England | turkey | H7N3 |
1966 | Ontario (Canada) | turkey | H5N9 |
1976 | Victoria (Australia) | chicken | H7N7 |
1979 | Germany | chicken | H7N7 |
1979 | England | turkey | H7N7 |
1983 | Pennsylvania (USA)* | chicken,turkey | H5N2 |
1983 | Ireland | turkey | H5N8 |
1985 | Victoria (Australia) | chicken | H7N7 |
1991 | England | turkey | H5N1 |
1992 | Victoria (Australia) | chicken | H7N3 |
1994 | Queensland (Australia) | chicken | H7N3 |
1994 | Mexico* | chicken | H5N2 |
1994 | Pakistan* | chicken | H7N3 |
1997 | New South Wales (Australia) | chicken | H7N4 |
1997 | Hong Kong (China)* | chicken | H5N1 |
1997 | Italy | chicken | H5N2 |
1999 | Italy* | turkey | H7N1 |
2002 | Hong Kong (China) | chicken | H5N1 |
2002 | Chile | chicken | H7N3 |
2003 | Netherlands* | chicken | H7N7 |
*Outbreaks with significant spread to numerous farms, resulting in great economic losses. Most other outbreaks involved little or no spread from the initially infected farms. |
1979: "More than 400 harbor seals, most of them immature, died along the New England coast between December 1979 and October 1980 of acute pneumonia associated with influenza virus, A/Seal/Mass/1/180 (H7N7)." [12]
1995: "[V]accinated birds can develop asymptomatic infections that allow virus to spread, mutate, and recombine (ProMED-mail, 2004j). Intensive surveillance is required to detect these “silent epidemics” in time to curtail them. In Mexico, for example, mass vaccination of chickens against epidemic H5N2 influenza in 1995 has had to continue in order to control a persistent and evolving virus (Lee et al., 2004)." [13]
1997: "Influenza A viruses normally seen in one species sometimes can cross over and cause illness in another species. For example, until 1997, only H1N1 viruses circulated widely in the U.S. pig population. However, in 1997, H3N2 viruses from humans were introduced into the pig population and caused widespread disease among pigs. Most recently, H3N8 viruses from horses have crossed over and caused outbreaks in dogs." [14]
2000: "In California, poultry producers kept their knowledge of a recent H6N2 avian influenza outbreak to themselves due to their fear of public rejection of poultry products; meanwhile, the disease spread across the western United States and has since become endemic." [15] [16]
2003: In Netherlands H7N7 influenza virus infection broke out in poultry on several farms. [17]
2004: In North America, the presence of avian influenza strain H7N3 was confirmed at several poultry farms in British Columbia in February 2004. As of April 2004, 18 farms had been quarantined to halt the spread of the virus. CDC detailed analysis
2005: Tens of millions of birds died of H5N1 influenza and hundreds of millions of birds were culled to protect humans from H5N1. H5N1 is endemic in birds in southeast Asia and represents a long term pandemic threat.
2006: H5N1 infects and kills wild birds in Europe and poultry in Africa.
- Swine flu
- Main article: Swine Flu
- Swine flu (or "pig influenza") refers to varieties of influenza virus A that affect swine. These include genotypes of H1N1, H1N2 and H3N2.
- Horse flu
- Main article: Horse flu
- Horse flu (or "Equine influenza") refers to varieties of influenza virus A that affect horses. Horse 'flu viruses were only isolated in 1956. There are two main types of virus called equine-1 (H7N7) which commonly affects horse heart muscle and equine-2 (H3N8) which is usually more severe.
- Dog flu
- Main article: Dog flu
- Dog flu (or "canine influenza") refers to varieties of influenza virus A that affect dogs. The equine influenza virus H3N8 was found to infect and kill greyhound race dogs that had died from a respiratory illness at a Florida racetrack in January 2004.
- H3N8
Human influenza virus
"Human influenza virus" usually refers to those subtypes that spread widely among humans. H1N1, H1N2, and H3N2 are the only known avian flu virus subtypes currently circulating among humans. [18]
Genetic factors in distinguishing between "human flu viruses" and "avian flu viruses" include:
- PB2: (RNA polymerase): Amino acid (or residue) position 627 in the PB2 protein encoded by the PB2 RNA gene. Until H5N1, all known avian influenza viruses "had a Glu at position 627, while all human influenza viruses had a lysine."
- HA: (hemagglutinin): "Avian influenza HA bind alpha 2-3 sialic acid receptors while human influenza HA bind alpha 2-6 sialic acid receptors. Swine influenza viruses have the ability to bind both types of sialic acid receptors." [19].
In humans, avian flu viruses cause similar symptoms to other types of flu. [20] These include fever, cough, sore throat, muscle aches, conjunctivitis and, in severe cases, severe breathing problems and pneumonia that may be fatal. The severity of the infection will depend to a large part on the state of the infected person's immune system and if the victim has been exposed to the strain before, and is therefore partially immune. In one case, a boy with H5N1 experienced diarrhea followed rapidly by a coma without developing respiratory or flu-like symptoms, suggesting non-standard symptoms. [21]
The avian influenza subtypes that have been confirmed in humans, ordered by the number of known human deaths, are: H1N1 caused "Spanish Flu", H2N2 caused "Asian Flu", H3N2 caused "Hong Kong Flu", H5N1 is the current pandemic threat, H7N7 has unusual zoonotic potential, H1N2 is currently endemic in humans and pigs, H9N2, H7N2, H7N3, H10N7.
All avian influenza (AI) viruses are type A influenza virus in the virus family of Orthomyxoviridae and all known strains of influenza A virus infect birds. Influenzavirus type A is subdivided into subtypes based on hemagglutinin (H) and neuraminidase (N) protein spikes from the central virus core. There are 16 H types, each with up to 9 N subtypes, yielding a potential for 144 different H and N combinations.
In addition, avian influenza viruses may fall into one of 2 pathotypes: low (LPAI) and high (HPAI) pathogenicity, based on their virulence in poultry populations. Avian influenzavirus H5 and H7 strains are found in both "low pathogenic” or “high pathogenic” forms; influenza H9 virus has been identified only in a “low pathogenic” form.
It is feared that if a strain of avian influenza virus to which humans have not been previously exposed undergoes antigenic shift to the point where it can cross the species barrier from birds to humans, the new subtype created could be both highly contagious and highly lethal in humans. If a human infected with influenzavirus also acquires H5N1, a mutant strain of bird flu that can be transmitted from human to human could form. Such a subtype could cause a global pandemic similar to the Spanish flu that killed up to 50 million people in 1918.
- H1N1
- Main article: H1N1
- A variant of H1N1 was responsible for the Spanish flu pandemic that killed some 50 million to 100 million people worldwide over about a year in 1918 and 1919 [22]. A different variant exists in pig populations. Controversy arose in October, 2005, after the H1N1 genome was published in the journal, Science. Many fear that this information could be used for bioterrorism.
- "When he compared the 1918 virus with today's human flu viruses, Dr. Taubenberger noticed that it had alterations in just 25 to 30 of the virus's 4,400 amino acids. Those few changes turned a bird virus into a killer that could spread from person to person." [23]
- H2N2
- Main article: H2N2
- The Asian Flu was a pandemic outbreak of H2N2 avian influenza that originated in China in 1957, spread worldwide that same year during which a flu vaccine was developed, lasted until 1958 and caused between one and four million deaths.
- H3N2
- Main article: H3N2
- H3N2 evolved from H2N2 by antigenic shift and caused the Hong Kong Flu pandemic of 1968 and 1969 that killed up to 750,000. (Detailed chart of its evolution here.) "An early-onset, severe form of influenza A (H3N2) made headlines when it claimed the lives of several children in the United States in late 2003." [24]
- The dominant strain of annual flu in January 2006 is H3N2. Measured resistance to the standard antiviral drugs amantadine and rimantadine in H3N2 has increased from 1% in 1994 to 12% in 2003 to 91% in 2005. [25] [26]
- "[C]ontemporary human H3N2 influenza viruses are now endemic in pigs in southern China and can reassort with avian H5N1 viruses in this intermediate host." [27]
- H5N1
- Main article: H5N1
- H5N1 is a highly pathogenic form of avian influenzavirus. Since 1997, outbreaks of H5N1 flu have caused the death or culling of tens of millions of birds. Over 100 people have been infected by H5N1, with a mortality rate of over 50%. H5N1 has been the focus of much concern amid warnings that the H5N1 strain will likely evolve into a form that causes a global human pandemic with a very high mortality rate. As of November 1, 2005, 184 cases of infections in humans, resulting in 85 deaths, have been confirmed outside of China.
- H7N7
- Main article: H7N7
- H7N7 has unusual zoonotic potential. In 2003 in Netherlands 89 people were confirmed to have H7N7 influenza virus infection following an outbreak in poultry on several farms. One death was recorded.
- H1N2
- Main article: H1N2
- H1N2 is currently endemic in both human and pig populations. The new A(H1N2) strain appears to have resulted from the reassortment of the genes of the currently circulating influenza A(H1N1) and A(H3N2) subtypes. The hemagglutinin protein of the A(H1N2) virus is similar to that of the currently circulating A(H1N1) viruses and the neuraminidase protein is similar to that of the current A(H3N2) viruses.
- H9N2
- Main article: H9N2
- Low pathogenic avian influenza A (H9N2) infection was confirmed in 1999, in China and Hong Kong in two children, and in 2003 in Hong Kong in one child. All three fully recovered. CDC
- H7N2
- Main article: H7N2
- One person in New York in 2003 and one person in Virginia in 2002 were found to have serologic evidence of infection with H7N2. Both fully recovered. [28]
- H7N3
- Main article: H7N3
- In North America, the presence of avian influenza strain H7N3 was confirmed at several poultry farms in British Columbia in February 2004. As of April 2004, 18 farms had been quarantined to halt the spread of the virus. Two cases of humans with avian influenza have been confirmed in that region. "Symptoms included conjunctivitis and mild influenza-like illness." CDC detailed analysis Both fully recovered.
- H10N7
- Main article: H10N7
- In 2004 in Egypt H10N7 is reported for the first time in humans. It caused illness in two infants in Egypt. One child’s father is a poultry merchant. [29]
Sources
- Gibbs, W. Waut & Soares, Christine (Nov. 2005). "Preparing for a Pandemic". Scientific American, p. 23–31.
- "Reining in bird flu: Answer may lie with reverse engineering". (Nov. 6, 2005). New Sunday Times, p. F18.
- "Three million Asians may die". (Nov. 5, 2005). New Straits Times, p. 28.
- "Avian Influenza Factsheet". World Health Organization. Retrieved November 16th, 2005.
Further reading
- Official sources (also see H5N1)
- Avian influenza and Influenza Pandemics from the Centers for Disease Control and Prevention
- Avian influenza FAQ from the World Health Organization
- Avian influenza information from the Food and Agriculture Organization
- U.S. Government's avian influenza information website
- General information (also see Flu)
- Influenza Report 2006 Online book. Research level quality information. Highly recommended.
- Special issue on avian flu from Nature
- Overview of H5N1 from New England Journal of Medicine
- Pandemic Influenza: Domestic Preparedness Efforts Congressional Research Service Report on Pandemic Preparedness.
- A guide to bird flu and its symptoms from BBC Health
- A Variety of Avian Flu Images and Pictures
- Avian flu, bioterror, animals (page in an online book) "Highly pathogenic avian influenza virus is on every top ten list available for potential agricultural bioweapon agents"
- 'The Threat of Bird Flu' : HealthPolitics.com
- Is a Global Flu Pandemic Imminent? from Infection Control Today.
- Bird Flu is a Real Pandemic Threat to Humans by Leonard Crane, author of Ninth Day of Creation.
- Links to Bird Flu pictures (Hardin MD/Univ of Iowa)
- News
- Current status (Google news of avian+OR+bird+flu+OR+influenza)
- Flu Breaking News Avian flu, common symptom, flu vaccine and flu shot and latest news
- Global Pandemic News : 24 X 7 online news feeds on the threat of Bird Flu and a Global Pandemic
It should be an early Christmas for Democrats - as the GOP has self destructed - but where are they? Why are they silent? I wonder when we can shame the archreactionaries off the bench of the Supreme Court? Will politics matter if billions die due to the Bush Junta 2? - Sparks
2 Comments:
At 10:55 PM , Anonymous said...
More cheesecake!
And none of those skanky looking pretend blondes ...
yuck
more loli from japan kekekeke
At 11:38 AM , Coat said...
Japanese girls are Sparky's dept.
Smoke and mirror fakery are the PP Guru's dept.
He thrives on scams and ROBs.
Otherwise, there would be nothing for him to blog about while he's unemployed.
~
PP Guru
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